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Hytrin: Hytrin (Terazosin) is prescribed to reduce high blood pressure. It may be used alone or in combination with other blood pressure lowering drugs, such as HydroDIURIL (a diuretic) or Inderal, a beta blocker.

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Hytrin

Generic Name: terazosin hydrochloride
Dosage Form: Tablets
Description


Hytrin (terazosin hydrochloride), an alpha-1-selective adrenoceptor blocking agent, is a quinazoline derivative represented by the following chemical name and structural formula:

(RS)-Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetra-hydro-2-furanyl)carbonyl]-, monohydrochloride, dihydrate.



Terazosin hydrochloride is a white, crystalline substance, freely soluble in water and isotonic saline and has a molecular weight of 459.93. Hytrin tablets (terazosin hydrochloride tablets) for oral ingestion are supplied in four dosage strengths containing terazosin hydrochloride equivalent to 1 mg, 2 mg, 5 mg, or 10 mg of terazosin.
Inactive Ingredients

1 mg tablet: corn starch, lactose, magnesium stearate, povidone and talc.

2 mg tablet: corn starch, FD&C Yellow No. 6, lactose, magnesium stearate, povidone and talc.

5 mg tablet: corn starch, iron oxide, lactose, magnesium stearate, povidone and talc.

10 mg tablet: corn starch, D&C Yellow No. 10, FD&C Blue No. 2, lactose, magnesium stearate, povidone and talc.
Hytrin - Clinical Pharmacology
Pharmacodynamics
A. Benign Prostatic Hyperplasia (BPH)

The symptoms associated with BPH are related to bladder outlet obstruction, which is comprised of two underlying components: a static component and a dynamic component. The static component is a consequence of an increase in prostate size. Over time, the prostate will continue to enlarge. However, clinical studies have demonstrated that the size of the prostate does not correlate with the severity of BPH symptoms or the degree of urinary obstruction.1 The dynamic component is a function of an increase in smooth muscle tone in the prostate and bladder neck, leading to constriction of the bladder outlet. Smooth muscle tone is mediated by sympathetic nervous stimulation of alpha-l adrenoceptors, which are abundant in the prostate, prostatic capsule and bladder neck. The reduction in symptoms and improvement in urine flow rates following administration of terazosin is related to relaxation of smooth muscle produced by blockade of alpha-l adrenoceptors in the bladder neck and prostate. Because there are relatively few alpha-l adrenoceptors in the bladder body, terazosin is able to reduce the bladder outlet obstruction without affecting bladder contractility.

Terazosin has been extensively studied in 1222 men with symptomatic BPH. In three placebo-controlled studies, symptom evaluation and uroflowmetric measurements were performed approximately 24 hours following dosing. Symptoms were systematically quantified using the Boyarsky Index. The questionnaire evaluated both obstructive (hesitancy, intermittency, terminal dribbling, impairment of size and force of stream, sensation of incomplete bladder emptying) and irritative (nocturia, daytime frequency, urgency, dysuria) symptoms by rating each of the 9 symptoms from 0-3, for a total score of 27 points. Results from these studies indicated that terazosin statistically significantly improved symptoms and peak urine flow rates over placebo as follows
 
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Hytrin: Hytrin (Terazosin) is prescribed to reduce high blood pressure. It may be used alone or in combination with other blood pressure lowering drugs, such as HydroDIURIL (a diuretic) or Inderal, a beta blocker.

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Seek medical attention right away if any of these SEVERE side effects occur:

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This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:

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General information:
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If using Hytrin for an extended period of time, obtain refills before your supply runs out.

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Hytrin: Hytrin (Terazosin) is prescribed to reduce high blood pressure. It may be used alone or in combination with other blood pressure lowering drugs, such as HydroDIURIL (a diuretic) or Inderal, a beta blocker.

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Possible side effects of Hytrin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; dry mouth; feeling of a whirling motion; headache; lightheadedness; nasal congestion; nausea; weakness.
Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; chest pain; decreased sexual ability; difficulty breathing; easy bleeding or bruising; fainting; painful penile erection; pounding or tightness in the chest; ringing in the ears; swelling of the hands or feet.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include dizziness; weakness.
Proper storage of Hytrin :

Store capsules at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hytrin out of the reach of children and away from pets.
General information:
If you have any questions about Hytrin , please talk with your doctor, pharmacist, or other health care provider.
Hytrin is to be used only by the patient for whom it is prescribed. Do not share it with other people. Do not use it for other health conditions.
If your symptoms do not improve or if they become worse, check with your doctor.
If using Hytrin for an extended period of time, obtain refills before your supply runs out.

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Before taking Hytrin

You should not use Hytrin if you are allergic to terazosin.

Hytrin can affect the pupils of your eyes during cataract surgery. If you have cataract surgery during your treatment with terazosin, tell the surgeon ahead of time that you take terazosin. Do not stop using the medication before surgery unless your surgeon tells you to.

FDA pregnancy category C. It is not known whether Hytrin is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether terazosin passes into breast milk or if it could harm a nursing baby. Do not use Hytrin without telling your doctor if you are breast-feeding a baby.


How should I take Hytrin?

Take Hytrin exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take each dose with a full glass of water. Hytrin lowers blood pressure and may cause dizziness or fainting, especially when you first start taking it, or when you start taking it again. To avoid falling, take the first dose of Hytrin at bedtime. You may wish to continue taking this medication only at bedtime if it causes you to feel light-headed.

You may feel very dizzy when you first wake up. Be careful when standing or sitting up from a lying position.

If you stopped taking Hytrin for any reason and have started taking it again, you may feel especially dizzy or light-headed after your first few doses.

To be sure this medication is helping your condition, your blood pressure or prostate will need to be checked on a regular basis. It is important that you not miss any scheduled visits to your doctor.

If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms.

Store Hytrin at room temperature away from moisture and heat.
 
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Product info: Blood Pressure - Hytrin
Hytrin: Hytrin (Terazosin) is prescribed to reduce high blood pressure. It may be used alone or in combination with other blood pressure lowering drugs, such as HydroDIURIL (a diuretic) or Inderal, a beta blocker.

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Product description

Hytrin is also prescribed to relieve the symptoms of benign prostatic hyperplasia or BPH. BPH is an enlargement of the prostate gland that surrounds the urinary canal. It leads to the following symptoms:
• A weak or interrupted stream when urinating
• A feeling that you cannot empty your bladder completely
• A feeling of delay when you start to urinate
• A need to urinate often, especially at night
• A feeling that you must urinate right away
Hytrin relaxes the tightness of a certain type of muscle in the prostate and at the opening of the bladder. This can reduce the severity of the symptoms.


Common uses

Terazosin is used for treatment urinary obstruction caused by enlarged prostate. Hytrin increases urine flow by relaxing the smooth muscles of prostate. Terazosin is used together with another medications for treatment of high blood pressure as well.
Before using

Contact your doctor or pharmacist if you have any questions or concerns about using this medicine. Do not take Hytrin if you are sensitive to it or have ever had an allergic reaction to it.

Directions

You may take Hytrin with or without food. Take your first dose at bedtime. Do not take more than the 1 milligram your doctor has prescribed.
-If you miss a dose...
Take it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at the same time.
-Storage instructions...
Store at room temperature in a cool, dry place. Protect from light.

Cautions

• The first dose of this medicine may cause dizziness, light-headedness or fainting. For this reason you should take the first dose, and preferably each dose, just before retiring to bed at night. Take care when moving from lying down to sitting or standing, particularly if you wake up in the night, until you know how this medicine affects you. If you feel dizzy or light-headed at any time during treatment, sit or lie down until the symptoms pass.
• This medicine may cause fatigue and dizziness. You should take care when performing potentially hazardous activites, such as driving or operating machinery, until you know how this medicine affects you and are sure you can perform such activities safely.
• Alcohol may enhance the blood pressure lowering effect of this medicine, which may result in dizziness or fainting.
• If you miss a dose of this medicine take it as soon as you remember, unless it is nearly time for your next scheduled dose, in which case leave out the missed dose and continue as normal. Do not take two doses at the same time, as this can make your blood pressure drop too low. If you miss treatment for more than a few days for any reason, then consult your doctor, as you may need to re-start the medicine at a lower dose.
 
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